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SEND PDF Practice Q&A's Total Questions: 200
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MRCPUK SEND Exam Syllabus Topics:

SectionObjectives
Reproductive Endocrinology- Gonadal Disorders
  • 1. Male hypogonadism
  • 2. Disorders of puberty and fertility
  • 3. Polycystic ovary syndrome
  • 4. Female reproductive endocrinology
Diabetes Mellitus- Management
  • 1. Lifestyle interventions
  • 2. Oral and injectable therapies
  • 3. Insulin therapy
  • 4. Technology and glucose monitoring
- Diagnosis and Classification
  • 1. Gestational diabetes
  • 2. Type 1 diabetes
  • 3. Type 2 diabetes
  • 4. Other specific types of diabetes
- Complications
  • 1. Microvascular complications
  • 2. Perioperative and inpatient diabetes management
  • 3. Acute metabolic emergencies
  • 4. Macrovascular complications
Thyroid Disorders- Thyroid Disease
  • 1. Thyroiditis and special clinical situations
  • 2. Hyperthyroidism
  • 3. Thyroid nodules and cancer
  • 4. Hypothyroidism
General Endocrinology- Integrated Clinical Practice
  • 1. Endocrine hypertension
  • 2. Neuroendocrine disorders
  • 3. Investigation, imaging and interpretation of endocrine tests
  • 4. Genetic endocrine syndromes
Pituitary and Hypothalamic Disorders- Pituitary Disease
  • 1. Pituitary hormone deficiency
  • 2. Pituitary tumors
  • 3. Pituitary hormone excess
  • 4. Hypothalamic disorders
Calcium and Bone Metabolism- Parathyroid and Metabolic Bone Disease
  • 1. Disorders of calcium, phosphate and vitamin D metabolism
  • 2. Hypoparathyroidism
  • 3. Hyperparathyroidism
  • 4. Osteoporosis
Adrenal Disorders- Adrenal Disease
  • 1. Cushing syndrome
  • 2. Pheochromocytoma and adrenal incidentaloma
  • 3. Adrenal insufficiency
  • 4. Primary aldosteronism

MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:

1. A 25-year-old woman presented with a solitary nodule in the right lobe of her thyroid gland.
Investigations:
serum thyroid-stimulating hormone0.45 mU/L (0.4-5.0)
serum free T420.7 pmol/L (10.0-22.0)
The presence of which feature would most increase the likelihood of malignancy?

A) increased peripheral vascularity of nodule on Doppler ultrasound
B) elevated serum thyroglobulin concentration
C) high titre of thyroid peroxidase antibodies
D) microcalcification seen within the nodule on ultrasound scan
E) size of nodule >1.0 cm in maximum diameter


2. A 54-year-old man was referred to the diabetes foot clinic with a plantar foot ulcer of 3 months' duration under the right first metatarsal head. He had a 10-year history of type 2 diabetes mellitus. He lived alone and had to do his own shopping and cleaning.
On examination, the ulcer was 3 ? 2 cm in area, 4 mm in depth, and had a clean granulating base. He had strong palpable pedal pulses and sensory neuropathy in both feet.
What is the most effective intervention to heal this ulcer?

A) ambulatory vacuum-assisted pump therapy
B) Manuka honey-impregnated wound dressing
C) total contact casting
D) long-term oral antibiotics
E) removable pressure-relieving boot


3. A 64-year-old man presented with palpitations, fatigue and malaise. Two months previously, he had sustained an acute myocardial infarction complicated by ventricular tachycardia and cardiac arrest, and had been discharged taking amiodarone 200 mg daily.
On examination, he appeared well, his pulse was 90 beats per minute and regular, and he
had mild tremor of his hands but no other abnormal signs.
Investigations:
serum thyroid-stimulating hormone6.2 mU/L (0.4-5.0)
serum free T418.2 pmol/L (10.0-22.0)
serum free T34.8 pmol/L (3.0-7.0)
What is the most appropriate next step in management?

A) start levothyroxine
B) repeat thyroid function tests in 2 months
C) repeat thyroid function tests in 12 months
D) isotope scan of thyroid
E) discontinue amiodarone


4. A 26-year-old woman presented acutely with abdominal pain. On examination, her blood pressure was 124/72 mmHg.
Investigations:
24-h urinary dopamine10 000 nmol (<3100)
24-h urinary adrenaline43 nmol (<144)
24-h urinary noradrenaline146 nmol (<570)
CT scan of abdomen3-cm left para-aortic mass
She underwent surgical exploration and removal of the lesion, which proved to be a paraganglioma. One local lymph node, removed at the same time, was also positive for the presence of tumour.
What is the most likely underlying genetic syndrome?

A) Gardner's syndrome
B) multiple endocrine neoplasia type 2a
C) succinate dehydrogenase type B mutation
D) von Hippel-Lindau syndrome
E) neurofibromatosis type 1 mutation


5. A 37-year-old woman presented with a 2-year history of increasingly frequent flushing episodes. She described alternating loose bowel motions and constipation. She had also noted menstrual irregularity. She had no respiratory symptoms. She denied headache or chest pain, but complained of palpitations.
On examination, she appeared well. Her blood pressure was 128/82 mmHg.
Investigations:
serum thyroid-stimulating hormone0.8 mU/L (0.4-5.0)
What is the most appropriate next investigation?

A) fasting plasma gut hormones
B) urinary 5-hydroxyindoleacetic acid
C) urinary metanephrines
D) serum gonadotrophins
E) plasma metanephrines


Solutions:

Question # 1
Answer: D
Question # 2
Answer: C
Question # 3
Answer: B
Question # 4
Answer: C
Question # 5
Answer: D

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